{"id":3968,"date":"2025-08-01T14:38:45","date_gmt":"2025-08-01T14:38:45","guid":{"rendered":"https:\/\/clariceabreu.com.br\/?page_id=3968"},"modified":"2025-08-27T22:23:12","modified_gmt":"2025-08-27T22:23:12","slug":"outras-malformacoes","status":"publish","type":"page","link":"https:\/\/clariceabreu.com.br\/en\/outras-malformacoes\/","title":{"rendered":"Other malformations"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3968\" class=\"elementor elementor-3968\" data-elementor-post-type=\"page\">\n\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-7f78ab3 e-flex e-con-boxed e-con e-parent\" data-id=\"7f78ab3\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-fc3449f e-flex e-con-boxed e-con e-child\" data-id=\"fc3449f\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18d0c18 elementor-widget elementor-widget-jet-headline\" data-id=\"18d0c18\" data-element_type=\"widget\" data-widget_type=\"jet-headline.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"jet-headline jet-headline--direction-horizontal\"><span class=\"jet-headline__part jet-headline__first\"><span class=\"jet-headline__label\">Outras \n<\/span><\/span><span class=\"jet-headline__space\">&nbsp;<\/span><span class=\"jet-headline__part jet-headline__second\"><span class=\"jet-headline__label\">Malformations<\/span><\/span><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9192279 elementor-widget elementor-widget-text-editor\" data-id=\"9192279\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Citando os tipos espec\u00edficos de malforma\u00e7\u00f5es, ajudando na compreens\u00e3o do tema<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-e1121f2 e-flex e-con-boxed e-con e-parent\" data-id=\"e1121f2\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-083983b e-flex e-con-boxed e-con e-child\" data-id=\"083983b\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-16f9baa e-n-menu-mobile e-full_width e-n-menu-layout-horizontal elementor-widget elementor-widget-n-menu\" data-id=\"16f9baa\" data-element_type=\"widget\" data-settings=\"{&quot;menu_items&quot;:[{&quot;item_title&quot;:&quot;Apert&quot;,&quot;_id&quot;:&quot;4b692f2&quot;,&quot;item_link&quot;:{&quot;url&quot;:&quot;#apert&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;item_dropdown_content&quot;:&quot;&quot;,&quot;item_icon&quot;:{&quot;value&quot;:&quot;&quot;,&quot;library&quot;:&quot;&quot;},&quot;item_icon_active&quot;:null,&quot;element_id&quot;:&quot;&quot;},{&quot;item_title&quot;:&quot;Crouzon&quot;,&quot;_id&quot;:&quot;a80deb6&quot;,&quot;item_link&quot;:{&quot;url&quot;:&quot;#crouzon&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;item_dropdown_content&quot;:&quot;no&quot;,&quot;item_icon&quot;:{&quot;value&quot;:&quot;&quot;,&quot;library&quot;:&quot;&quot;},&quot;item_icon_active&quot;:null,&quot;element_id&quot;:&quot;&quot;},{&quot;item_title&quot;:&quot;Pfeiffer&quot;,&quot;_id&quot;:&quot;ee3fa21&quot;,&quot;item_link&quot;:{&quot;url&quot;:&quot;#pfifer&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;item_dropdown_content&quot;:&quot;&quot;,&quot;item_icon&quot;:{&quot;value&quot;:&quot;&quot;,&quot;library&quot;:&quot;&quot;},&quot;item_icon_active&quot;:null,&quot;element_id&quot;:&quot;&quot;},{&quot;item_title&quot;:&quot;Hipertelorismo Orbit\\u00e1rio&quot;,&quot;item_link&quot;:{&quot;url&quot;:&quot;#hipertelorismo&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;_id&quot;:&quot;d6dfcd9&quot;,&quot;item_dropdown_content&quot;:&quot;no&quot;,&quot;item_icon&quot;:{&quot;value&quot;:&quot;&quot;,&quot;library&quot;:&quot;&quot;},&quot;item_icon_active&quot;:null,&quot;element_id&quot;:&quot;&quot;}],&quot;item_position_horizontal&quot;:&quot;center&quot;,&quot;item_position_horizontal_mobile&quot;:&quot;center&quot;,&quot;horizontal_scroll_mobile&quot;:&quot;disable&quot;,&quot;breakpoint_selector&quot;:&quot;mobile&quot;,&quot;content_width&quot;:&quot;full_width&quot;,&quot;item_layout&quot;:&quot;horizontal&quot;,&quot;open_on&quot;:&quot;hover&quot;,&quot;horizontal_scroll&quot;:&quot;disable&quot;,&quot;menu_item_title_distance_from_content&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:0,&quot;sizes&quot;:[]},&quot;menu_item_title_distance_from_content_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;menu_item_title_distance_from_content_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"mega-menu.default\">\n\t\t\t\t\t\t\t<nav class=\"e-n-menu\" data-widget-number=\"240\" aria-label=\"Menu\">\n\t\t\t\t\t<button class=\"e-n-menu-toggle\" id=\"menu-toggle-240\" aria-haspopup=\"true\" aria-expanded=\"false\" aria-controls=\"menubar-240\" aria-label=\"Switch menu\">\n\t\t\t<span class=\"e-n-menu-toggle-icon e-open\">\n\t\t\t\t<svg class=\"e-font-icon-svg e-eicon-menu-bar\" viewbox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M104 333H896C929 333 958 304 958 271S929 208 896 208H104C71 208 42 237 42 271S71 333 104 333ZM104 583H896C929 583 958 554 958 521S929 458 896 458H104C71 458 42 487 42 521S71 583 104 583ZM104 833H896C929 833 958 804 958 771S929 708 896 708H104C71 708 42 737 42 771S71 833 104 833Z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t<span class=\"e-n-menu-toggle-icon e-close\">\n\t\t\t\t<svg class=\"e-font-icon-svg e-eicon-close\" viewbox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M742 167L500 408 258 167C246 154 233 150 217 150 196 150 179 158 167 167 154 179 150 196 150 212 150 229 154 242 171 254L408 500 167 742C138 771 138 800 167 829 196 858 225 858 254 829L496 587 738 829C750 842 767 846 783 846 800 846 817 842 829 829 842 817 846 804 846 783 846 767 842 750 829 737L588 500 833 258C863 229 863 200 833 171 804 137 775 137 742 167Z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<div class=\"e-n-menu-wrapper\" id=\"menubar-240\" aria-labelledby=\"menu-toggle-240\">\n\t\t\t\t<ul class=\"e-n-menu-heading\">\n\t\t\t\t\t\t\t\t<li class=\"e-n-menu-item\">\n\t\t\t\t<div id=\"e-n-menu-title-2401\" class=\"e-n-menu-title e-anchor\">\n\t\t\t\t\t<a class=\"e-n-menu-title-container e-focus e-link\" href=\"#apert\" aria-current=\"page\">\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"e-n-menu-title-text\">\n\t\t\t\t\t\t\tApert\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t<li class=\"e-n-menu-item\">\n\t\t\t\t<div id=\"e-n-menu-title-2402\" class=\"e-n-menu-title e-anchor\">\n\t\t\t\t\t<a class=\"e-n-menu-title-container e-focus e-link\" href=\"#crouzon\" aria-current=\"page\">\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"e-n-menu-title-text\">\n\t\t\t\t\t\t\tCrouzon\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t<li class=\"e-n-menu-item\">\n\t\t\t\t<div id=\"e-n-menu-title-2403\" class=\"e-n-menu-title e-anchor\">\n\t\t\t\t\t<a class=\"e-n-menu-title-container e-focus e-link\" href=\"#pfifer\" aria-current=\"page\">\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"e-n-menu-title-text\">\n\t\t\t\t\t\t\tPfeiffer\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t<li class=\"e-n-menu-item\">\n\t\t\t\t<div id=\"e-n-menu-title-2404\" class=\"e-n-menu-title e-anchor\">\n\t\t\t\t\t<a class=\"e-n-menu-title-container e-focus e-link\" href=\"#hipertelorismo\" aria-current=\"page\">\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"e-n-menu-title-text\">\n\t\t\t\t\t\t\tOrbital hypertelorism\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t<\/div>\n\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-2eca7e8 e-flex e-con-boxed e-con e-parent\" data-id=\"2eca7e8\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-5f23616 e-con-full e-flex e-con e-child\" data-id=\"5f23616\" data-element_type=\"container\" id=\"apert\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-2876b96 e-con-full e-flex e-con e-child\" data-id=\"2876b96\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-6eb048c e-con-full e-flex e-con e-child\" data-id=\"6eb048c\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f9f9e54 elementor-widget elementor-widget-jet-video\" data-id=\"f9f9e54\" data-element_type=\"widget\" data-widget_type=\"jet-video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-jet-video jet-elements\">\n<div class=\"jet-video jet-video--fa5-compat jet-video-aspect-ratio jet-video-aspect-ratio--16-9\" data-settings=\"{&quot;lightbox&quot;:false,&quot;autoplay&quot;:false}\"><iframe class=\"jet-video-iframe\" allowfullscreen allow=\"autoplay;encrypted-media\" title=\"YouTube video player\" data-lazy-load=\"https:\/\/www.youtube.com\/embed\/D8hHhAsC3wc?feature=oembed&amp;start&amp;end&amp;wmode=opaque&amp;autoplay=0&amp;loop=0&amp;controls=1&amp;mute=0&amp;rel=0&amp;modestbranding=0\"><\/iframe>\n<div class=\"jet-video__overlay jet-video__overlay--custom-bg\" style=\"background-image: url(https:\/\/i.ytimg.com\/vi_webp\/D8hHhAsC3wc\/maxresdefault.webp);\">\n<div class=\"jet-video__play-button\" role=\"button\" tabindex=\"0\" aria-label=\"Video play button\"><span class=\"jet-elements-icon jet-video__play-button-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-play\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M424.4 214.7L72.4 6.6C43.8-10.3 0 6.1 0 47.9V464c0 37.5 40.7 60.1 72.4 41.3l352-208c31.4-18.5 31.5-64.1 0-82.6z\"><\/path><\/svg><\/span>\t<span class=\"elementor-screen-only\">Play video<\/span>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-fec41f1 e-con-full e-flex e-con e-child\" data-id=\"fec41f1\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ee432d elementor-widget elementor-widget-heading\" data-id=\"1ee432d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Apert\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0228aa8 elementor-blockquote--skin-quotation elementor-blockquote--button-color-official elementor-widget elementor-widget-blockquote\" data-id=\"0228aa8\" data-element_type=\"widget\" data-widget_type=\"blockquote.default\">\n\t\t\t\t\t\t\t<blockquote class=\"elementor-blockquote\">\n\t\t\t<p class=\"elementor-blockquote__content\">\n\t\t\t\tVoc\u00ea j\u00e1 ouviu falar da S\u00edndrome de Apert? Apesar de ser pouco conhecida, essa s\u00edndrome gen\u00e9tica atinge um a cada 100 a 160 mil nascidos vivos.\t\t\t<\/p>\n\t\t\t\t\t<\/blockquote>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-3deb1bb e-con-full e-flex e-con e-child\" data-id=\"3deb1bb\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-0c4904f e-con-full e-flex e-con e-child\" data-id=\"0c4904f\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6fcaef5 elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"6fcaef5\" data-element_type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t\t        <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-6fcaef5\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"6fcaef5\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n    <div class=\"eael-accordion-list\">\n                <div id=\"o-que-a-sndrome-de-apert\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-1171\"><span class=\"eael-advanced-accordion-icon-closed\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-plus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-advanced-accordion-icon-opened\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-minus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-accordion-tab-title\">O que \u00e9 a S\u00edndrome de Apert?<\/span><svg aria-hidden=\"true\" class=\"fa-toggle e-font-icon-svg e-fas-angle-right\" viewbox=\"0 0 256 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M224.3 273l-136 136c-9.4 9.4-24.6 9.4-33.9 0l-22.6-22.6c-9.4-9.4-9.4-24.6 0-33.9l96.4-96.4-96.4-96.4c-9.4-9.4-9.4-24.6 0-33.9L54.3 103c9.4-9.4 24.6-9.4 33.9 0l136 136c9.5 9.4 9.5 24.6.1 34z\"><\/path><\/svg><\/div><div id=\"elementor-tab-content-1171\" class=\"eael-accordion-content clearfix\" data-tab=\"1\" aria-labelledby=\"o-que-a-sndrome-de-apert\"><p>A s\u00edndrome de Apert \u00e9 uma malforma\u00e7\u00e3o cong\u00eanita grave, que associa uma uni\u00e3o precoce dos ossos do cr\u00e2nio e da base do cr\u00e2nio (craniofacioestenose).<\/p><p>Essa s\u00edndrome \u00e9 respons\u00e1vel, portanto, por causar o desenvolvimento anormal da estrutura craniana e facial de uma pessoa. Por isso, os beb\u00eas portadores dessa malforma\u00e7\u00e3o nascem com o formato da cabe\u00e7a e a face diferentes.<\/p><p>A S\u00edndrome de Apert s\u00f3 acontece naqueles que possuem uma muta\u00e7\u00e3o em um dos genes respons\u00e1veis pelos fibroblastos, que s\u00e3o encarregados de promover a uni\u00e3o dos ossos do cr\u00e2nio ainda durante o desenvolvimento do beb\u00ea no \u00fatero da m\u00e3e. Com isso, h\u00e1 uma uni\u00e3o precoce e err\u00f4nea dos ossos da calota craniana e da base do cr\u00e2nio, o que pode prejudicar a est\u00e9tica do cr\u00e2nio, da face e tamb\u00e9m o desenvolvimento do c\u00e9rebro da crian\u00e7a.<\/p><p>Al\u00e9m disso, os beb\u00eas portadores de Apert tamb\u00e9m nascem com jun\u00e7\u00f5es dos dedos das m\u00e3os e dos p\u00e9s que parecem estar todos \u201ccolados\u201d, o que tamb\u00e9m \u00e9 conhecido como sindactilia complexa. Essa sindactilia de m\u00faltiplos dedos \u00e9 uma caracter\u00edstica definidora da s\u00edndrome e ajuda a fazer o diagn\u00f3stico e a diferenciar de outras s\u00edndromes de craniofacioestenoses, como a S\u00edndrome de Crouzon e a S\u00edndrome de Pfeiffer.<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"quais-so-os-sintomas-da-sndrome\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"2\" aria-controls=\"elementor-tab-content-1172\"><span class=\"eael-advanced-accordion-icon-closed\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-plus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-advanced-accordion-icon-opened\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-minus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-accordion-tab-title\">Quais s\u00e3o os sintomas da s\u00edndrome?<\/span><svg aria-hidden=\"true\" class=\"fa-toggle e-font-icon-svg e-fas-angle-right\" viewbox=\"0 0 256 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M224.3 273l-136 136c-9.4 9.4-24.6 9.4-33.9 0l-22.6-22.6c-9.4-9.4-9.4-24.6 0-33.9l96.4-96.4-96.4-96.4c-9.4-9.4-9.4-24.6 0-33.9L54.3 103c9.4-9.4 24.6-9.4 33.9 0l136 136c9.5 9.4 9.5 24.6.1 34z\"><\/path><\/svg><\/div><div id=\"elementor-tab-content-1172\" class=\"eael-accordion-content clearfix\" data-tab=\"2\" aria-labelledby=\"quais-so-os-sintomas-da-sndrome\"><p>Devido \u00e0 jun\u00e7\u00e3o prematura dos ossos do cr\u00e2nio, o c\u00e9rebro fica muito constrito e pode ter o seu crescimento e desenvolvimento prejudicados. A jun\u00e7\u00e3o dos ossos da base do cr\u00e2nio, por outro lado, impede que a face cres\u00e7a normalmente. Com isso, os portadores da S\u00edndrome de Apert ter\u00e3o algumas caracter\u00edsticas f\u00edsicas reconhec\u00edveis, s\u00e3o elas:<\/p><ul><li>Face afundada ou retra\u00edda;<\/li><li>Olhos distantes um do outro, devido ao crescimento anormal do cr\u00e2nio;<\/li><li>Uma testa longa e, consequentemente, uma cabe\u00e7a de formato mais longo do que o normal.<\/li><\/ul><p>Al\u00e9m disso, \u00e9 poss\u00edvel que o portador da s\u00edndrome possua os seguintes sintomas: apneia do sono (dist\u00farbio em que a pessoa p\u00e1ra de respirar por alguns segundos enquanto est\u00e1 dormindo), problemas de audi\u00e7\u00e3o e sucessivas infec\u00e7\u00f5es no ouvido e crises constantes de sinusite.<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"causas-da-sndrome-de-apert\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"3\" aria-controls=\"elementor-tab-content-1173\"><span class=\"eael-advanced-accordion-icon-closed\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-plus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-advanced-accordion-icon-opened\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-minus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-accordion-tab-title\">Causas da S\u00edndrome de Apert<\/span><svg aria-hidden=\"true\" class=\"fa-toggle e-font-icon-svg e-fas-angle-right\" viewbox=\"0 0 256 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M224.3 273l-136 136c-9.4 9.4-24.6 9.4-33.9 0l-22.6-22.6c-9.4-9.4-9.4-24.6 0-33.9l96.4-96.4-96.4-96.4c-9.4-9.4-9.4-24.6 0-33.9L54.3 103c9.4-9.4 24.6-9.4 33.9 0l136 136c9.5 9.4 9.5 24.6.1 34z\"><\/path><\/svg><\/div><div id=\"elementor-tab-content-1173\" class=\"eael-accordion-content clearfix\" data-tab=\"3\" aria-labelledby=\"causas-da-sndrome-de-apert\"><p>Existem dois motivos que podem levar ao desenvolvimento da S\u00edndrome de Apert:<\/p><ol><li>Um dos progenitores possui o gene: Nesse caso, um dos pais possui em seu DNA o gene que causa a s\u00edndrome. Dessa forma, como o beb\u00ea carrega metade dos genes do pai e a outra metade da m\u00e3e, esse pode ser um dos motivos que leva ao desenvolvimento dessa malforma\u00e7\u00e3o.<\/li><\/ol><ol start=\"2\"><li>Muta\u00e7\u00e3o gen\u00e9tica desconhecida: Assim como diz o nome, pode acontecer casos em que nenhum dos pais possuem a carga gen\u00e9tica da s\u00edndrome, mas, mesmo assim, acontece uma muta\u00e7\u00e3o durante a gesta\u00e7\u00e3o e o beb\u00ea desenvolve o Apert. Mesmo ap\u00f3s mais de um s\u00e9culo de sua descoberta, ainda n\u00e3o foi poss\u00edvel saber qual \u00e9 a raz\u00e3o da muta\u00e7\u00e3o. Entretanto, alguns estudiosos sobre o assunto afirmam que gesta\u00e7\u00e3o em idade avan\u00e7ada pode desencadear esse acidente gen\u00e9tico.<\/li><\/ol><p>Devido \u00e0s suas caracter\u00edsticas f\u00edsicas, o diagn\u00f3stico da S\u00edndrome de Apert pode ser feito logo ap\u00f3s o nascimento do beb\u00ea ou tamb\u00e9m a partir de exames gen\u00e9ticos para confirmar a exist\u00eancia da muta\u00e7\u00e3o.<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"como-tratar-a-sndrome-de-apert\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"4\" aria-controls=\"elementor-tab-content-1174\"><span class=\"eael-advanced-accordion-icon-closed\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-plus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-advanced-accordion-icon-opened\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-minus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-accordion-tab-title\">Como tratar a s\u00edndrome de Apert?<\/span><svg aria-hidden=\"true\" class=\"fa-toggle e-font-icon-svg e-fas-angle-right\" viewbox=\"0 0 256 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M224.3 273l-136 136c-9.4 9.4-24.6 9.4-33.9 0l-22.6-22.6c-9.4-9.4-9.4-24.6 0-33.9l96.4-96.4-96.4-96.4c-9.4-9.4-9.4-24.6 0-33.9L54.3 103c9.4-9.4 24.6-9.4 33.9 0l136 136c9.5 9.4 9.5 24.6.1 34z\"><\/path><\/svg><\/div><div id=\"elementor-tab-content-1174\" class=\"eael-accordion-content clearfix\" data-tab=\"4\" aria-labelledby=\"como-tratar-a-sndrome-de-apert\"><p>Apesar de n\u00e3o existir uma cura para a s\u00edndrome, \u00e9 poss\u00edvel tratar essa malforma\u00e7\u00e3o com cirurgias pl\u00e1sticas. Esses procedimentos cir\u00fargicos s\u00e3o respons\u00e1veis por corrigir as altera\u00e7\u00f5es no cr\u00e2nio do beb\u00ea e os casos de sindactilia. Al\u00e9m disso, a cirurgia permite que o c\u00e9rebro do rec\u00e9m-nascido consiga se desenvolver e evita que aconte\u00e7a algum dano mental.<\/p><p>Para melhor efic\u00e1cia do tratamento, as cirurgias para corre\u00e7\u00e3o dos sinais craniofaciais da S\u00edndrome de Apert s\u00e3o divididas em tr\u00eas partes:<\/p><ol><li>Cirurgia para remodelamento craniano: feita nos primeiros meses de vida da crian\u00e7a, essa primeira cirurgia tem como objetivo separar as partes que foram fundidas precocemente no cr\u00e2nio, como uma tentativa de expandir o espa\u00e7o intracraniano e permitir que o c\u00e9rebro cres\u00e7a e se desenvolva normalmente.<\/li><\/ol><ol start=\"2\"><li>Cirurgia para avan\u00e7o da face: feita em torno dos 6-8 anos de idade, a cirurgia consiste em \u201ccorrigir\u201d os ossos da face, visto que, conforme a crian\u00e7a se desenvolve, a face se mant\u00e9m retra\u00edda e n\u00e3o cresce normalmente. Com isso, o cirurgi\u00e3o respons\u00e1vel tentar\u00e1 colocar os ossos da regi\u00e3o do nariz e maxila na posi\u00e7\u00e3o em que deveriam estar.<\/li><\/ol><ol start=\"3\"><li>Cirurgia para corre\u00e7\u00e3o da dist\u00e2ncia aumentada entre os olhos (hipertelorismo): a terceira e \u00faltima cirurgia \u00e9 feita para corrigir a regi\u00e3o dos olhos, diminuindo o espa\u00e7o entre eles.<\/li><\/ol><p>\u00c9 importante saber que, apesar de o tratamento craniofacial ser dividido em tr\u00eas cirurgias, isso n\u00e3o significa que n\u00e3o ser\u00e1 preciso outras opera\u00e7\u00f5es durante todo o processo, visto que alguns casos podem ser mais graves do que outros.<\/p><p>Em rela\u00e7\u00e3o ao tratamento das sindactilias das m\u00e3os e p\u00e9s, \u00e9 poss\u00edvel realizar a separa\u00e7\u00e3o dos 10 dedos das m\u00e3os e dos p\u00e9s na grande maioria dos casos. Essa parte do tratamento pode ser dividida em duas etapas cir\u00fargicas, que podem ser iniciadas ainda no primeiro ano de vida.<\/p><p>Al\u00e9m dos procedimentos cir\u00fargicos, outro jeito de tratar a S\u00edndrome de Apert inclui tratamentos para melhorar a condi\u00e7\u00e3o de vida do portador, por exemplo: medica\u00e7\u00e3o para tratar sinusites e otites, tratamento intensivo para apneia do sono e utiliza\u00e7\u00e3o de col\u00edrios diariamente para prevenir secura nos olhos, entre outros tratamentos que melhorem os sintomas da s\u00edndrome.<\/p><\/div>\n                <\/div><div class=\"eael-accordion-list\">\n                <div id=\"dvidas-sobre-a-sndrome-de-apert\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"5\" aria-controls=\"elementor-tab-content-1175\"><span class=\"eael-advanced-accordion-icon-closed\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-plus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-advanced-accordion-icon-opened\"><svg aria-hidden=\"true\" class=\"fa-accordion-icon e-font-icon-svg e-fas-minus\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span><span class=\"eael-accordion-tab-title\">D\u00favidas sobre a S\u00edndrome de Apert<\/span><svg aria-hidden=\"true\" class=\"fa-toggle e-font-icon-svg e-fas-angle-right\" viewbox=\"0 0 256 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M224.3 273l-136 136c-9.4 9.4-24.6 9.4-33.9 0l-22.6-22.6c-9.4-9.4-9.4-24.6 0-33.9l96.4-96.4-96.4-96.4c-9.4-9.4-9.4-24.6 0-33.9L54.3 103c9.4-9.4 24.6-9.4 33.9 0l136 136c9.5 9.4 9.5 24.6.1 34z\"><\/path><\/svg><\/div><div id=\"elementor-tab-content-1175\" class=\"eael-accordion-content clearfix\" data-tab=\"5\" aria-labelledby=\"dvidas-sobre-a-sndrome-de-apert\"><ol><li>Qual \u00e9 a expectativa de vida para os portadores da S\u00edndrome de Apert: A expectativa de vida para uma pessoa que nasceu com a s\u00edndrome pode variar. Tudo depende do quanto a anomalia afetou o desenvolvimento do beb\u00ea. Por exemplo, uma crian\u00e7a que conseguiu sobreviver aos primeiros anos de vida e n\u00e3o teve mais nenhum tipo de complica\u00e7\u00e3o, pode ter uma expectativa de vida igual \u00e0 de uma que nasceu sem Apert.<\/li><\/ol><ol start=\"2\"><li>Se eu tiver essa s\u00edndrome, meu filho tamb\u00e9m ter\u00e1? Por ser uma s\u00edndrome gen\u00e9tica, caso um dos progenitores tiver o gene, existe 50% de chances do seu filho tamb\u00e9m nascer com essa malforma\u00e7\u00e3o craniofacial.<\/li><\/ol><ol start=\"3\"><li>Caso eu tenha, existe alguma forma de evitar que meu filho nas\u00e7a com a s\u00edndrome? Se voc\u00ea ou seu parceiro (a) apresentam o gene da s\u00edndrome, o mais indicado \u00e9 que utilizar o m\u00e9todo de fertiliza\u00e7\u00e3o in vitro para gerar um beb\u00ea. Dessa forma, ser\u00e1 poss\u00edvel selecionar o embri\u00e3o que n\u00e3o possui nenhum sinal de Apert. Entretanto, \u00e9 importante saber que, mesmo que o embri\u00e3o inicialmente n\u00e3o tenha o gene, \u00e9 poss\u00edvel que a muta\u00e7\u00e3o se desenvolva durante a gesta\u00e7\u00e3o.<\/li><\/ol><ol start=\"4\"><li>Meu filho ter\u00e1 um desenvolvimento mental normal? Para que portadores da S\u00edndrome de Apert tenham um desenvolvimento normal, \u00e9 preciso que a cirurgia de tratamento craniano seja feita o mais r\u00e1pido poss\u00edvel para evitar que o pouco espa\u00e7o ou a malforma\u00e7\u00e3o afetem o crescimento do c\u00e9rebro. Com as cirurgias corretas e com acompanhamento m\u00e9dico, \u00e9 muito prov\u00e1vel que o beb\u00ea consiga se desenvolver normalmente.<\/li><\/ol><\/div>\n                <\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-98c84b3 e-con-full e-flex e-con e-child\" data-id=\"98c84b3\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-18c0033 e-con-full e-flex e-con e-child\" data-id=\"18c0033\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-03a99e9 elementor-widget elementor-widget-image-gallery\" data-id=\"03a99e9\" data-element_type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-1' class='gallery galleryid-3968 gallery-columns-2 gallery-size-full'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"03a99e9\" data-elementor-lightbox-title=\"apert1\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDAwNSwidXJsIjoiaHR0cHM6XC9cL2NsYXJpY2VhYnJldS5jb20uYnJcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzA4XC9hcGVydDEuanBnIiwic2xpZGVzaG93IjoiMDNhOTllOSJ9\" href='https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/apert1.jpg'><img fetchpriority=\"high\" decoding=\"async\" width=\"444\" height=\"309\" src=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/apert1.jpg\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/apert1.jpg 444w, https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/apert1-300x209.jpg 300w\" sizes=\"(max-width: 444px) 100vw, 444px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"03a99e9\" data-elementor-lightbox-title=\"apert2\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDAwNiwidXJsIjoiaHR0cHM6XC9cL2NsYXJpY2VhYnJldS5jb20uYnJcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzA4XC9hcGVydDIuanBnIiwic2xpZGVzaG93IjoiMDNhOTllOSJ9\" href='https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/apert2.jpg'><img decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/apert2.jpg\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/apert2.jpg 768w, https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/apert2-300x200.jpg 300w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-83e0a20 e-con-full e-flex e-con e-child\" data-id=\"83e0a20\" data-element_type=\"container\" id=\"crouzon\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-aca3446 e-con-full e-flex e-con e-child\" data-id=\"aca3446\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-718a289 e-con-full e-flex e-con e-child\" data-id=\"718a289\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-39e642d elementor-widget elementor-widget-heading\" data-id=\"39e642d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Crouzon\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41b16b9 elementor-widget elementor-widget-text-editor\" data-id=\"41b16b9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>S\u00edndrome descrita por Crouzon em 1912, ela associa uma cranioestenose e uma hipoplasia do ter\u00e7o m\u00e9dio facial. A cranioestenose, na maioria dos casos, acomete as duas suturas coronais.<\/p><p>A altera\u00e7\u00e3o facial \u00e9 caracter\u00edstica: hiperteleorbitismo (afastamento das \u00f3rbitas), exorbitismo (com \u00f3rbitas rasas, provocando o efeito de \u201colhos saltados\u201d) e retrus\u00e3o de todo o ter\u00e7o m\u00e9dio facial. Habitualmente pouco marcante ao nascimento, ela tende a se tornar mais aparente em torno da idade de 2 anos e se agrava progressivamente.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-1cb0306 e-con-full e-flex e-con e-child\" data-id=\"1cb0306\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f82d56 elementor-widget elementor-widget-image\" data-id=\"6f82d56\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img alt=\"\" decoding=\"async\" width=\"280\" height=\"280\" src=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/crouzon1.jpg\" class=\"attachment-full size-full wp-image-4016\" srcset=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/crouzon1.jpg 280w, https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/crouzon1-150x150.jpg 150w\" sizes=\"(max-width: 280px) 100vw, 280px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-6dfcbf7 e-con-full e-flex e-con e-child\" data-id=\"6dfcbf7\" data-element_type=\"container\" id=\"pfifer\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-c34f88a e-con-full e-flex e-con e-child\" data-id=\"c34f88a\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-c8d702c e-con-full e-flex e-con e-child\" data-id=\"c8d702c\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-98d6492 elementor-widget elementor-widget-jet-video\" data-id=\"98d6492\" data-element_type=\"widget\" data-widget_type=\"jet-video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-jet-video jet-elements\">\n<div class=\"jet-video jet-video--fa5-compat jet-video-aspect-ratio jet-video-aspect-ratio--16-9\" data-settings=\"{&quot;lightbox&quot;:false,&quot;autoplay&quot;:false}\"><iframe class=\"jet-video-iframe\" allowfullscreen allow=\"autoplay;encrypted-media\" title=\"YouTube video player\" data-lazy-load=\"https:\/\/www.youtube.com\/embed\/5xxNAd-7NKQ?feature=oembed&amp;start&amp;end&amp;wmode=opaque&amp;autoplay=0&amp;loop=0&amp;controls=1&amp;mute=0&amp;rel=0&amp;modestbranding=0\"><\/iframe>\n<div class=\"jet-video__overlay jet-video__overlay--custom-bg\" style=\"background-image: url(https:\/\/i.ytimg.com\/vi_webp\/5xxNAd-7NKQ\/maxresdefault.webp);\">\n<div class=\"jet-video__play-button\" role=\"button\" tabindex=\"0\" aria-label=\"Video play button\"><span class=\"jet-elements-icon jet-video__play-button-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-play\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M424.4 214.7L72.4 6.6C43.8-10.3 0 6.1 0 47.9V464c0 37.5 40.7 60.1 72.4 41.3l352-208c31.4-18.5 31.5-64.1 0-82.6z\"><\/path><\/svg><\/span>\t<span class=\"elementor-screen-only\">Play video<\/span>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-d8e2fd1 e-con-full e-flex e-con e-child\" data-id=\"d8e2fd1\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cd6c951 elementor-widget elementor-widget-heading\" data-id=\"cd6c951\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pfeiffer\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3640504 elementor-widget elementor-widget-text-editor\" data-id=\"3640504\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>S\u00edndrome descrita por Rudolf Pfeiffer em 1964, ela apresenta uma braquicefalia (fechamento das suturas cranianas coronais) associada a sindactilias membranosas vari\u00e1veis das m\u00e3os e p\u00e9s e sobretudo um alargamento dos polegares e dos ded\u00f5es dos p\u00e9s (\u201cded\u00e3o do p\u00e9 aumentado\u201d), com um desvio marcante para dentro. Uma braquidactilia, uma estenose dos cotovelos, e at\u00e9 mesmo sinfalangia s\u00e3o frequentemente descritos.<\/p><p>M\u00e3os e p\u00e9s na S\u00edndrome de Pfeiffer, com sindactilias membranosas vari\u00e1veis e o aumento e o desvio caracter\u00edstico dos polegares e ded\u00f5es dos p\u00e9s<\/p><p>As formas graves, com o cr\u00e2nio em trevo, s\u00e3o descritas. Nestes casos, a dismorfia craniana \u00e9 muito importante, devido a um bombeamento consider\u00e1vel das fossas temporais e de uma estenose lateral das regi\u00f5es frontoparietais, levando a um aspecto trilobado visto de frente. A hidrocefalia cong\u00eanita \u00e9 constante. Essa dismorfia maior, muitas vezes chamada s\u00edndrome do cr\u00e2nio em trevo, pode igualmente ser observada nas s\u00edndromes de Apert e na forma precoce da s\u00edndrome de Crouzon.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-5bd107e e-con-full e-flex e-con e-child\" data-id=\"5bd107e\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-3a7d6ff e-con-full e-flex e-con e-child\" data-id=\"3a7d6ff\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4533cc4 elementor-widget elementor-widget-text-editor\" data-id=\"4533cc4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Cr\u00e2nio com altera\u00e7\u00e3o caracter\u00edstica em formato de trevo.<\/p><p>\u00a0<\/p><p>A S\u00edndrome de Pfeiffer \u00e9 rara, com uma incid\u00eancia aproximada de 1 para cada 100.000 indiv\u00edduos. Ocorre cranioestenoses em associa\u00e7\u00e3o com polegares e ded\u00f5es dos p\u00e9s curtos e desviados para dentro. A fus\u00e3o prematura das suturas coronais e lambd\u00f3ides pode ser acompanhada ocasionalmente da fus\u00e3o ainda da sutura sagital, levando \u00e0 forma anormal do cr\u00e2nio. Ocorre uma apar\u00eancia facial caracter\u00edstica, com alargamento da cabe\u00e7a e achatamento do occipital, alongamento da regi\u00e3o frontal, hipoplasia (menor desenvolvimento) do ter\u00e7o m\u00e9dio da face, nariz curto com dorso nasal baixo e afastamento dos olhos (hipertelorismo ocular). Os pacientes geralmente apresentam olhos proeminentes (proptose ocular) devido \u00e0s \u00f3rbitas serem muito rasas.<\/p><p>\u00a0<\/p><p>Os polegares e os ded\u00f5es dos p\u00e9s s\u00e3o curtos e tortos, com um desvio t\u00edpico. Ocorre jun\u00e7\u00e3o (sindactilia) do segundo e terceiro dedos. Anomalias adicionais podem incluir: retardo mental em graus variados, estenose de aqueduto cerebral com consequente hidrocefalia, implanta\u00e7\u00e3o baixa das orelhas, estenose (estreitamento) do conduto auditivo externo, infec\u00e7\u00f5es de ouvido recorrentes, e menos frequentemente, hidronefrose, rins p\u00e9lvicos, bexiga pouco desenvolvida (hipopl\u00e1sica).<\/p><p>\u00a0<\/p><p>Pacientes com S\u00edndrome de Pfeiffer podem apresentar obstru\u00e7\u00e3o de vias a\u00e9reas superiores devido \u00e0 retrus\u00e3o do ter\u00e7o m\u00e9dio da face.<\/p><p>\u00a0<\/p><p>De acordo com as caracter\u00edsticas cl\u00ednicas, a S\u00edndrome de Pfeiffer pode ser dividida em 3 subtipos:<\/p><p>Tipo 1: S\u00edndrome de Pfeiffer \u201ccl\u00e1ssica\u201d, com manifesta\u00e7\u00f5es leves incluindo braquicefalia, hipoplasia do ter\u00e7o m\u00e9dio da face e anomalias de dedos das m\u00e3os e dos p\u00e9s. Est\u00e1 associada com desenvolvimento neurol\u00f3gico e intelectual normais e geralmente tem um bom progn\u00f3stico.<\/p><p>\u00a0<\/p><p>Tipo 2: caracteriza-se pela deformidade do cr\u00e2nio trilobado, com uma proemin\u00eancia no topo e uma em cada lado da cabe\u00e7a, dando um aspecto em forma de \u201c folha de trevo\u201d (tamb\u00e9m chamado de Kleeblattsch\u00e4del), embora essa caracter\u00edstica n\u00e3o seja exclusiva da S\u00edndrome de Pfeiffer, podendo ocorrer em outras s\u00edndromes ou mesmo isoladamente. Apresenta ainda proptose (olhos saltados) grave, anomalias de dedos das m\u00e3os e p\u00e9s, anquilose (jun\u00e7\u00e3o) ou estenose de cotovelo, atraso de desenvolvimento mental e complica\u00e7\u00f5es neurol\u00f3gicas. O cr\u00e2nio em forma de trevo pode causar limita\u00e7\u00e3o ao crescimento cerebral e a proptose grave pode causar perdas visuais importantes.<\/p><p>\u00a0<\/p><p>Tipo 3: semelhante ao tipo 2, por\u00e9m sem deformidade do cr\u00e2nio em forma de trevo. A aus\u00eancia do cr\u00e2nio em forma de trevo pode tornar dif\u00edcil estabelecer o diagn\u00f3stico. Os tipos 2 e 3 ocorrem esporadicamente e apresentam um risco aumentado de morte precoce devido ao comprometimento neurol\u00f3gico grave e problemas respirat\u00f3rios. Uma superposi\u00e7\u00e3o cl\u00ednica entre os tr\u00eas tipos pode ocorrer.<\/p><p>\u00a0<\/p><p><strong>Diagnosticando a S\u00edndrome de Pfeiffer<\/strong><\/p><p>\u00a0<\/p><p>O diagn\u00f3stico \u00e9 geralmente cl\u00ednico, baseado na presen\u00e7a de cranioestenoses e polegares e ded\u00f5es dos p\u00e9s alterados. Geneticamente, ocorrem muta\u00e7\u00f5es nos genes dos receptores dos fatores de crescimento dos fibroblastos (do ingl\u00eas: fibroblast growth factor receptor \u2013 FGFR1 e FGFR2). Esses genes atuam na sinaliza\u00e7\u00e3o das c\u00e9lulas em resposta ao seu ambiente, regulando processos de prolifera\u00e7\u00e3o, diferencia\u00e7\u00e3o e migra\u00e7\u00e3o celular. Uma muta\u00e7\u00e3o em um desses genes causa uma sinaliza\u00e7\u00e3o prolongada, que pode provocar a matura\u00e7\u00e3o precoce das c\u00e9lulas \u00f3sseas e fus\u00e3o prematura dos ossos do cr\u00e2nio, das m\u00e3os e dos p\u00e9s.<\/p><p>Faz diagn\u00f3stico diferencial com outras s\u00edndromes de craniofacioestenoses, como as S\u00edndromes de Crouzon e Apert, discutidas em outro t\u00f3pico. De fato, as semelhan\u00e7as cl\u00ednicas s\u00e3o grandes, principalmente no que diz respeito ao aspecto orbit\u00e1rio (\u00f3rbitas rasas com proptose ocular) e \u00e0 retrus\u00e3o do ter\u00e7o m\u00e9dio da face, embora geneticamente sejam distintas.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-d5bc03e e-con-full e-flex e-con e-child\" data-id=\"d5bc03e\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-2c68960 e-con-full e-flex e-con e-child\" data-id=\"2c68960\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f586f5f elementor-widget elementor-widget-image-gallery\" data-id=\"f586f5f\" data-element_type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-2' class='gallery galleryid-3968 gallery-columns-2 gallery-size-full'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"f586f5f\" data-elementor-lightbox-title=\"Cr\u00e2nio com altera\u00e7\u00e3o caracter\u00edstica em formato de trevo\" data-elementor-lightbox-description=\"Cr\u00e2nio com altera\u00e7\u00e3o caracter\u00edstica em formato de trevo\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDAzMCwidXJsIjoiaHR0cHM6XC9cL2NsYXJpY2VhYnJldS5jb20uYnJcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzA4XC9wZmlmZXIyLmpwZyIsInNsaWRlc2hvdyI6ImY1ODZmNWYifQ%3D%3D\" href='https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/pfifer2.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"566\" height=\"276\" src=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/pfifer2.jpg\" class=\"attachment-full size-full\" alt=\"Cr\u00e2nio com altera\u00e7\u00e3o caracter\u00edstica em formato de trevo\" aria-describedby=\"gallery-2-4030\" srcset=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/pfifer2.jpg 566w, https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/pfifer2-300x146.jpg 300w\" sizes=\"(max-width: 566px) 100vw, 566px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-2-4030'>\n\t\t\t\tCr\u00e2nio com altera\u00e7\u00e3o caracter\u00edstica em formato de trevo\n\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"f586f5f\" data-elementor-lightbox-title=\"M\u00e3os e p\u00e9s na S\u00edndrome de Pfeiffer, com sindactilias membranosas vari\u00e1veis e o aumento e o desvio caracter\u00edstico dos polegares e ded\u00f5es dos p\u00e9s\" data-elementor-lightbox-description=\"M\u00e3os e p\u00e9s na S\u00edndrome de Pfeiffer, com sindactilias membranosas vari\u00e1veis e o aumento e o desvio caracter\u00edstico dos polegares e ded\u00f5es dos p\u00e9s\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDAzMSwidXJsIjoiaHR0cHM6XC9cL2NsYXJpY2VhYnJldS5jb20uYnJcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzA4XC9wZmlmZXIxLmpwZyIsInNsaWRlc2hvdyI6ImY1ODZmNWYifQ%3D%3D\" href='https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/pfifer1.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"427\" height=\"179\" src=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/pfifer1.jpg\" class=\"attachment-full size-full\" alt=\"M\u00e3os e p\u00e9s na S\u00edndrome de Pfeiffer, com sindactilias membranosas vari\u00e1veis e o aumento e o desvio caracter\u00edstico dos polegares e ded\u00f5es dos p\u00e9s\" aria-describedby=\"gallery-2-4031\" srcset=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/pfifer1.jpg 427w, https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/pfifer1-300x126.jpg 300w\" sizes=\"(max-width: 427px) 100vw, 427px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-2-4031'>\n\t\t\t\tM\u00e3os e p\u00e9s na S\u00edndrome de Pfeiffer, com sindactilias membranosas vari\u00e1veis e o aumento e o desvio caracter\u00edstico dos polegares e ded\u00f5es dos p\u00e9s\n\t\t\t\t<\/figcaption><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-7ccbb11 e-con-full e-flex e-con e-child\" data-id=\"7ccbb11\" data-element_type=\"container\" id=\"hipertelorismo\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-c2deaf8 e-con-full e-flex e-con e-child\" data-id=\"c2deaf8\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-0b31cd6 e-con-full e-flex e-con e-child\" data-id=\"0b31cd6\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4532c46 elementor-widget elementor-widget-image\" data-id=\"4532c46\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"425\" height=\"321\" src=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/h1.jpg\" class=\"attachment-large size-large wp-image-4035\" alt=\"Medida da fenda palpebral m\u00e9dia de 28-30mm\" srcset=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/h1.jpg 425w, https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/h1-300x227.jpg 300w\" sizes=\"(max-width: 425px) 100vw, 425px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-03439af e-con-full e-flex e-con e-child\" data-id=\"03439af\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e04be12 elementor-widget elementor-widget-heading\" data-id=\"e04be12\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Orbital hypertelorism\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae4dc49 elementor-widget elementor-widget-text-editor\" data-id=\"ae4dc49\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>O termo hipertelorismo orbit\u00e1rio ou hiperteleorbitismo ou simplesmente hipertelorismo, corresponde ao aumento da dist\u00e2ncia entre as \u00f3rbitas, ou dist\u00e2ncia interorbital aumentada. A dist\u00e2ncia entre as \u00f3rbitas pode ser obtida medindo-se a dist\u00e2ncia entre os dacrions, ou o ponto onde as suturas frontal, nasal e lacrimal convergem sobre a crista lacrimal anterior, ou seja, a dist\u00e2ncia entre as margens orbit\u00e1rias mediais ou internas.<\/p><p>Pode ocorrer um aumento da dist\u00e2ncia entre os cantos mediais dos olhos sem hipertelorismo verdadeiro, como acontece nos traumas de face em que ocorre telecanto traum\u00e1tico. A dist\u00e2ncia entre as pupilas tamb\u00e9m n\u00e3o significa hipertelorismo, uma vez que no estrabismo divergente a dist\u00e2ncia interpupilar est\u00e1 aumentada, sem haver aumento da dist\u00e2ncia entre as \u00f3rbitas.<\/p><p>A dist\u00e2ncia normal entre as \u00f3rbitas varia de acordo com a idade do paciente, a ra\u00e7a e o g\u00eanero masculino ou feminino. Em geral, toma-se como medida padr\u00e3o no adulto a dist\u00e2ncia interorbital de 30mm.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-01d54b9 e-con-full e-flex e-con e-child\" data-id=\"01d54b9\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-0a32f5d e-con-full e-flex e-con e-child\" data-id=\"0a32f5d\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aa1bea6 elementor-widget elementor-widget-text-editor\" data-id=\"aa1bea6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Classifica\u00e7\u00e3o do Hipertelorismo<\/strong><\/p><p>\u00a0<\/p><p>O hipertelorismo pode ser classificado em leve, moderado ou grave conforme essa dist\u00e2ncia entre as \u00f3rbitas vai aumentando:<\/p><p>Leve: entre 30 e 34mm<\/p><p>Moderado: &gt;34 e &lt;40mm<\/p><p>Grave: acima de 40mm<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e25663d elementor-widget elementor-widget-image\" data-id=\"e25663d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img alt=\"\" loading=\"lazy\" decoding=\"async\" width=\"781\" height=\"525\" src=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/h2.png\" class=\"attachment-large size-large wp-image-4036\" srcset=\"https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/h2.png 781w, https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/h2-300x202.png 300w, https:\/\/clariceabreu.com.br\/wp-content\/uploads\/2025\/08\/h2-768x516.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-8cc6c2c e-con-full e-flex e-con e-child\" data-id=\"8cc6c2c\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a899fa4 elementor-widget elementor-widget-text-editor\" data-id=\"a899fa4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Causas de hipertelorismo<\/strong><\/p><p>O hipertelorismo orbit\u00e1rio est\u00e1 relacionado a malforma\u00e7\u00f5es cong\u00eanitas, seja por fatores gen\u00e9ticos ou extr\u00ednsecos. As principais causas de hipertelorismo s\u00e3o: fissuras raras de face, como a fissura 14 de Tessier, displasia frontonasal, displasia craniofrontonasal (componente gen\u00e9tico), encefaloceles frontais, naso-etmoidais, s\u00edndromes de Apert e Crouzon.<\/p><p>Alguns problemas est\u00e9ticos podem acompanhar o hipertelorismo,\u00a0 como encurtamento do nariz, fissura alar, ponta nasal b\u00edfida, fronte malformada, implanta\u00e7\u00e3o anormal da linha do cabelo, afastamento das sobrancelhas, formato anormal dos olhos, mal posicionamento da \u00f3rbita, distopia do canto lateral dos olhos, encurtamento ou hipoplasia da bochecha, retrus\u00e3o ou hipoplasia da maxila, obstru\u00e7\u00e3o ou alargamento do canal lacrimal, hipertrofia do subcut\u00e2neo da \u00e1rea orbito nasal.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-cbb8ead e-con-full e-flex e-con e-parent\" data-id=\"cbb8ead\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-6ba72ed e-flex e-con-boxed e-con e-child\" data-id=\"6ba72ed\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-e66d188 e-con-full e-flex e-con e-child\" data-id=\"e66d188\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-530e0bb elementor-widget elementor-widget-jet-headline\" data-id=\"530e0bb\" data-element_type=\"widget\" data-widget_type=\"jet-headline.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"jet-headline jet-headline--direction-horizontal\"><span class=\"jet-headline__part jet-headline__first\"><span class=\"jet-headline__label\">Videos<\/span><\/span><span class=\"jet-headline__space\">&nbsp;<\/span><span class=\"jet-headline__part jet-headline__second\"><span class=\"jet-headline__label\">on the subject<\/span><\/span><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f71433a elementor-widget elementor-widget-jet-blog-video-playlist\" data-id=\"f71433a\" data-element_type=\"widget\" data-widget_type=\"jet-blog-video-playlist.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-jet-blog-video-playlist jet-blog\"><div class=\"jet-blog-playlist jet-tumbs-horizontal jet-tumbs-v-pos- jet-tumbs-h-pos-bottom jet-scroll-regular\"  data-hide-index='&quot;&quot;' data-hide-duration='&quot;&quot;' data-hide-image='&quot;&quot;'>\n\t<div class=\"jet-blog-playlist__canvas\"><div class=\"jet-blog-playlist__canvas-overlay\"><\/div><\/div>\n\t<div class=\"jet-blog-playlist__items\">\n\t\t<div class=\"jet-blog-playlist__heading\">\n\t<span class=\"jet-blog-playlist__heading-icon jet-blog-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-play\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M424.4 214.7L72.4 6.6C43.8-10.3 0 6.1 0 47.9V464c0 37.5 40.7 60.1 72.4 41.3l352-208c31.4-18.5 31.5-64.1 0-82.6z\"><\/path><\/svg><\/span>\t<div class=\"jet-blog-playlist__heading-content\">\n\t\t<div class=\"jet-blog-playlist__heading-title\">Sobre Outras Malforma\u00e7\u00f5es<\/div>\t\t<div class=\"jet-blog-playlist__counter\"><span class=\"jet-blog-playlist__counter-val\">1<\/span>\/2 <span class=\"jet-blog-playlist__counter-suffix\">videos<\/span><\/div>\t<\/div>\n<\/div>\n\t\t<div class=\"jet-blog-playlist__items-list\">\n\t\t\t<div class=\"jet-blog-playlist__items-list-content\"><div class=\"jet-blog-playlist__item jet-blog-active\"  data-id='e9bc4a6' data-video_id='D8hHhAsC3wc' data-provider='youtube' data-html='&quot;&lt;iframe width=\\&quot;100%\\&quot; height=\\&quot;450\\&quot; src=\\&quot;https:\\\/\\\/www.youtube.com\\\/embed\\\/D8hHhAsC3wc?feature=oembed&amp;enablejsapi=1\\&quot; frameborder=\\&quot;0\\&quot; allow=\\&quot;accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\\&quot; referrerpolicy=\\&quot;strict-origin-when-cross-origin\\&quot; allowfullscreen title=\\&quot;Dra. Clarice Responde: S\\u00edndrome de Apert\\&quot;&gt;&lt;\\\/iframe&gt;&quot;' data-height='450' data-video_index='1' data-video_start='0'><div class=\"jet-blog-playlist__item-index\">\n\t<div class=\"jet-blog-playlist__item-index-num\">1<\/div>\n\t<div class=\"jet-blog-playlist__item-status jet-status-playing\"><i class=\"fas fa-play\" aria-hidden=\"true\"><\/i><\/div>\n\t<div class=\"jet-blog-playlist__item-status jet-status-paused\"><i class=\"fas fa-pause\" aria-hidden=\"true\"><\/i><\/div>\n<\/div>\n<div class=\"jet-blog-playlist__item-thumb\">\n\t<img decoding=\"async\" src=\"https:\/\/i.ytimg.com\/vi\/D8hHhAsC3wc\/hqdefault.jpg\" alt=\"Apert\" title=\"Apert\" class=\"jet-blog-playlist__item-thumb-img\">\n<\/div><div class=\"jet-blog-playlist__item-content\"><div class=\"jet-blog-playlist__item-title\">Apert<\/div><div class=\"jet-blog-playlist__item-duration\">13:27<\/div><\/div><\/div><div class=\"jet-blog-playlist__item\"  data-id='3f3e23b' data-video_id='5xxNAd-7NKQ' data-provider='youtube' data-html='&quot;&lt;iframe width=\\&quot;100%\\&quot; height=\\&quot;450\\&quot; src=\\&quot;https:\\\/\\\/www.youtube.com\\\/embed\\\/5xxNAd-7NKQ?feature=oembed&amp;enablejsapi=1\\&quot; frameborder=\\&quot;0\\&quot; allow=\\&quot;accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\\&quot; referrerpolicy=\\&quot;strict-origin-when-cross-origin\\&quot; allowfullscreen title=\\&quot;Dra. Clarice Abreu - Sindrome de Pfeiffer\\&quot;&gt;&lt;\\\/iframe&gt;&quot;' data-height='450' data-video_index='2' data-video_start='0'><div class=\"jet-blog-playlist__item-index\">\n\t<div class=\"jet-blog-playlist__item-index-num\">2<\/div>\n\t<div class=\"jet-blog-playlist__item-status jet-status-playing\"><i class=\"fas fa-play\" aria-hidden=\"true\"><\/i><\/div>\n\t<div class=\"jet-blog-playlist__item-status jet-status-paused\"><i class=\"fas fa-pause\" aria-hidden=\"true\"><\/i><\/div>\n<\/div>\n<div class=\"jet-blog-playlist__item-thumb\">\n\t<img decoding=\"async\" src=\"https:\/\/i.ytimg.com\/vi\/5xxNAd-7NKQ\/hqdefault.jpg\" alt=\"Pfeiffer\" title=\"Pfeiffer\" class=\"jet-blog-playlist__item-thumb-img\">\n<\/div><div class=\"jet-blog-playlist__item-content\"><div class=\"jet-blog-playlist__item-title\">Pfeiffer<\/div><div class=\"jet-blog-playlist__item-duration\">08:51<\/div><\/div><\/div><\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fbe4047 elementor-widget elementor-widget-spacer\" data-id=\"fbe4047\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Outras &nbsp;Malforma\u00e7\u00f5es Citando os tipos espec\u00edficos de malforma\u00e7\u00f5es, ajudando na compreens\u00e3o do tema Apert Crouzon Pfeiffer Hipertelorismo Orbit\u00e1rio Play Video Apert Voc\u00ea j\u00e1 ouviu falar da S\u00edndrome de Apert? Apesar de ser pouco conhecida, essa s\u00edndrome gen\u00e9tica atinge um a cada 100 a 160 mil nascidos vivos. O que \u00e9 a S\u00edndrome de Apert? A [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-3968","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/clariceabreu.com.br\/en\/wp-json\/wp\/v2\/pages\/3968","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clariceabreu.com.br\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/clariceabreu.com.br\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/clariceabreu.com.br\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/clariceabreu.com.br\/en\/wp-json\/wp\/v2\/comments?post=3968"}],"version-history":[{"count":0,"href":"https:\/\/clariceabreu.com.br\/en\/wp-json\/wp\/v2\/pages\/3968\/revisions"}],"wp:attachment":[{"href":"https:\/\/clariceabreu.com.br\/en\/wp-json\/wp\/v2\/media?parent=3968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}